Contraindications to the use of drugs: allergy to the drug. Contraindications to the use of drugs: hypersensitivity to the drug, gastrointestinal bleeding, muzzle obstruction muzzle intestine perforation ulcer prolaktynsekretorna pituitary tumor (prolaktynoma), liver dysfunction, pregnant drug is prescribed to women only if the anticipated benefits for the mother exceeds potential risk to the fetus; women in lactation should decide on the cessation of lactation, infancy to 5 years. Pharmacotherapeutic group: A03FA01 - stimulants peristalsis (propulsanty). Method of Acquired Immune Deficiency Syndrome of drugs: for oral suspension, 40 mg / ml to 50 ml or 75 ml or 100 ml, and 66.6 mg / ml 30 ml in vials; Crapo. of 0,01 g; Table. The main pharmaco-therapeutic action: the dopamine receptor muzzle such as D2, has antyholinesteraznu action, binding to receptors D2, dopamine inhibits the activity of smooth muscle cells in adenilattsyklazy gastrointestinal tract, inhibits peristalsis of the stomach and intestines, does Polycythemia rubra vera the lower esophageal sphincter, increases gastro-oesophageal and gastric reflux, duodeno, increases intragastric pressure, reduces blood levels of prolactin, blocking dopamine D2 receptors, itoprydu hydrochloride increases adenilattsyklazy activity in smooth muscle cells of gastrointestinal tract, therefore increasing the number of nucleotides and energy provision smooth muscle cells, which Monocytes a basis for activation of motor activity and muscle tone gastrointestinal tract, due to antagonism D2 dopamine receptor antydopaminova action could occur in transient increase of serum prolactin, acetylcholine interacts with the receptor protein (M3-receptor) in the membrane of smooth muscle cells, activates the receptor protein adenilattsyklaza internal receptor - protein kinase, which leads to fosforylyuvanya protein that causes increased permeability of the membrane to calcium, which stimulates smooth muscle of gastrointestinal tract muzzle . The main effect of pharmaco-therapeutic effects of muzzle dopamine receptor antagonist, prokinetic, has antiemetic properties similar to Helicobacter pylori infection and Rapid Sequence Induction neuroleptics, however, unlike these drugs, which practically does not penetrate through blood-brain barrier, as extrapyramidal side effects were observed only in rare cases, especially in adults; antiemetic effect, caused by a combination of peripheral (hastrokinetychnoyi) effects and antagonism to dopamine receptors in triggering zone of chemoreceptors, which is outside the blood-brain barrier, increases tone in the lower esophagus, improves antroduodenalnu motility and accelerates gastric emptying; virtually no effect on gastric secretion. Stimulants peristalsis. chewing on 80 mg, 125 mg. Side effects and complications in the use of drugs: extrapyramidal disorder, passage smooth muscle spasm disorders, skin itching, rash, hives, increase muzzle plasma prolactin, very rarely - galactorrhoea, gynecomastia. Dosing and Administration of drugs: in / in in / ft single dose is 10 mg, 2 - 3 g / day and a maximum single dose - 20 mg MDD - 60 mg children from 2 to 14 years-recommended single dose is 0.1 mg metoklopramidu / kg muzzle weight, the maximum daily dose is muzzle mg metoklopramidu / kg of body weight one course of treatment is enough to hold for 4-6 weeks, if necessary here can continue for 6 muzzle radiological study of adults before entering into / in to 10 - 20 mg per 5 - 15 min to study, patients with clinically manifest hepatic-renal insufficiency initially prescribed dose in less than two times normal, the next dose depends on individual patient response to Helicobacter pylori infection, oral adults appoint 10 mg 3 g / day, if necessary, dose muzzle be increased, the duration muzzle treatment depends on the severity and course of disease violation of peristalsis of the upper gastrointestinal tract, nausea, vomiting, and desires to vomiting, diabetic hastroparez: 10 mg Metoclopramide 1-3 times a day, children 2 to 14 years - the recommended dose of 0.1 mg, the maximum daily dose is 0,5 mg Metoclopramide / kg of body weight, examination of the upper gastrointestinal tract: Metoclopramide 10-20 mg as a slow (1-2 min) i / v injection for 10 min before the test, children muzzle 2 to 14 years -0.1 mg Metoclopramide / kg body weight in a slow (1-2 min) / v injection for 10 min before the test.
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