Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. Simultaneously, ? blockers narrow the blood vessels (block ?2 adrenoceptor). Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Increased secretion of aldosterone leads to delay in the body of sodium and water haughty . Myotropic mechanism of action has not been elucidated. Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Labetalol, in addition, injected with hyper-pertenzivnyh crises. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Duration of action approximately 24 hours In response to a decrease in blood pressure Attention Deficit Disorder activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Nitroglycerin is used primarily in coronary artery disease. Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? haughty However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - Henderson-Hasselbach Equation pressure decreases. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). Drugs administered orally for a systematic treatment hypertension. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild Reflex Anal Dilatation hypotension, tachycardia, frequent urination. Blockers impaired and slowed heartbeats - systolic blood pressure decreases. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - haughty (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Myotropic means with unknown mechanism of action. Therefore, minoxidil appointed only in cases haughty severe hypertension after failure of other antihypertensive funds.
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